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Mechanistic workflow of exercise-induced and engineered exosome therapy for target-tissue rewiring.

Journal: Frontiers in Cell and Developmental Biology

Article Title: Exerkine-loaded exosomes in muscle aging: a nexus of exercise, regeneration, and crosstalk

doi: 10.3389/fcell.2026.1706977

Figure Lengend Snippet: Mechanistic workflow of exercise-induced and engineered exosome therapy for target-tissue rewiring.

Article Snippet: Engineered Exosome Therapy Strategy: Therapeutic exosomes can be generated through three main approaches: (i) donor-cell preconditioning with exercise mimetics, (ii) post-isolation loading with specific therapeutic molecules, and (iii) surface functionalization with targeting ligands to enhance specificity.

Techniques: